Investigating the pivotal role of gut microbiota in cognitive disorders

Elham Akbari; Dawood Hossaini; Murtaza Haidary

doi:10.60141/AJID/V.2.I.1.9

Authors

Elham Akbari Khatam Al-Nabieen University https://orcid.org/0000-0001-7856-8948
Dawood Hossaini Khatam Al-Nabieen University https://orcid.org/0000-0001-7873-7617
Murtaza Haidary Khatam Al-Nabieen University https://orcid.org/0000-0002-7273-9088

DOI:

https://doi.org/10.60141/AJID/V.2.I.1.9

Keywords:

Cognitive disorders, microbiota, microbiota-gut-brain axis

Abstract

Background: The human intestine harbors a collection of microorganisms known as intestinal microbiota, which encompasses bacteria, archaea, and eukaryotes. However, bacteria reign supreme as the most prevalent members of the intestinal microbiota. Notably, the gut microbiota plays a crucial role in regulating various physiological functions of the human body. In addition to its influence on digestion, the gut microbiota also exerts control over the function of the brain and central nervous system, earning the enteric nervous system the title of the "second brain." The behavior and mood, as well as the progression of nervous system diseases like multiple sclerosis, autism, Alzheimer's, schizophrenia, and Parkinson's, can potentially be regulated by the intestinal microbiota. Through the intestinal nervous system, production of metabolites, stimulation of entero-endocrine cells, and the immune system, the gut microbiota plays a role in regulating the function of the central nervous system. Disturbances caused by improper nutrition, indiscriminate use of antibiotics, stress, anxiety, and depression are significant factors that can worsen these diseases and disrupt the balance of gut microbiota.

Author Biographies

Elham Akbari, Khatam Al-Nabieen University

Department of Biology and Microbiology, School of Medical Laboratory Technology, Khatam Al-Nabieen University, Kabul, Afghanistan

Dawood Hossaini, Khatam Al-Nabieen University

Department of Biology and Microbiology, School of Medical Laboratory Technology, Khatam Al-Nabieen University, Kabul, Afghanistan

Murtaza Haidary, Khatam Al-Nabieen University

Research and Technology Center, Khatam Al-Nabieen University, Kabul, Afghanistan.

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