3aa23dbf1902ae21f9d-62d0 20240702224655484 sayedhussain.mosawi@ghalib.edu.af:6ukb sayedhussain.mosawi@ghalib.edu.af WEB-FORM Afghanistan Journal of Infectious Diseases AJID 29596491 10.60141/1 https://www.ajid.ghalib.edu.af/index.php/ajid 07 01 2024 07 01 2024 2 2 10.60141/AJID/V.2.I.2 https://www.ajid.ghalib.edu.af/index.php/ajid/issue/view/11 Department of Parasitology, Toxoplasmosis Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Mazandaran, Sari, Iran. Eissa Soleymani Shadi Shayesteh Azar . Department of Infectious Diseases, Antimicrobial Resistance Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Keihan Shabankhani . Department of Infectious Diseases, Antimicrobial Resistance Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Seyed Reza Mirbadie . School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran Roya Najafi-Vosough Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran Mahdi Fakhar Iranian National Registry Center for Lophomoniasis and Toxoplasmosis, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran SARS-CoV-2 is the causative agent of COVID-19, an infection that can manifest with mild to severe respiratory symptoms. A 70-year-old man with COVID-19 and COPD presented to a hospital complaining of breathing difficulties. A sample was taken, leading to the finding of the Acanthamoeba parasite. Stenotrophomonas maltophilia, a bacterium known for its resistance to most antibiotics and its significance as a nosocomial pathogen, was identified. Furthermore, for the first time, the Gloeotinia fungus was discovered as an endosymbiont of Acanthamoeba. The patient underwent successful treatment and was discharged from the hospital. Immunocompromised people should be concerned about the increasing incidence of nosocomial infections. The presence of Acanthamoeba should not be overlooked in respiratory disorders, as it has the potential to carry numerous pathogenic microorganisms as endosymbionts. 07 01 2024 07 01 2024 105 108 10.60141/AJID/V.2.I.2/11 https://www.ajid.ghalib.edu.af/index.php/ajid/article/view/64